Emergency services responded to reports of a two vehicle road traffic crash on the Steve Irwin Way, Beerburrum around 2.15pm.
Fire crews used hydraulic cutting equipment to release two persons who were trapped.
These persons were both transported to the Royal Brisbane Hospital.
A 35-year-old woman was airlifted with serious head injuries in a critical condition and a 50-year-old woman was transported with abdomen pain in a stable condition.
A man was also treated on scene by paramedics and was transported to Caboolture Hospital with minor injuries.